Internet and relationship

The word â€Å"dating† and â€Å"relationship† varies a great deal from bygone eras and now. Innovation had a colossal effect of the cognizance of â€Å"hookups†, â€Å"friends†, and â€Å"friends with benefits†. Web, mobile phones, masses, and numerous different assets changed the manner in which adolescents consider the other gender or a similar sex too. Connections ended up being â€Å"the old fashion† and hookups are the best. In the first place, connections aren't that genuine any longer. Adolescents are searching for something new, meeting sexual, something to turn them on.Backbone is one of the most utilized locales in nowadays; it associates you to the world and let you meet another distinctive kind of individuals around the world. â€Å"Backbone is the most helpful apparatus for dating since the creation of the case of chocolates. It might likewise be the most hazardous danger to dating since terrible breath† (Fox, Stuart). Th is age for the most part ponders attaching with hot folks, pretty young ladies, kissing, engaging in sexual relations, embracing, and being a tease. Through web, two individuals can do a ton, they can visit, video cam, talk secretly; meet new individuals and a ton more.Internet isn't legitimate now and again. A great deal of sites and masses are impacting adolescents to do awful stuff or to race into things before now is the right time. Spine, Namespace, twitter, and numerous other interpersonal organization sites aren't private any longer. Anybody thinks about you, what you like and don't, your relationship status, and what you are searching for. â€Å"With person to person communication destinations, with Backbone, in the event that you click that you're seeing someone, [notifies] everybody that you're seeing someone. Its open telecom, this isn't a piece of a decent relationship† (Fox, Stuart).Dating isn't about adoration from the start site, or holding up by her home. It i sn't about feelings any longer, it's just about what a young lady or a person needs. They need something new, something to discuss or feel pleased. â€Å"Social organizing has made a variety of new dating rules, making the old style â€Å"wait three days before calling† appear to be interesting by comparison† (Fox, Stuart). With respect to me, I see that this sort of connections and the love of the web use is a risky circumstance. Young people Just need to do what others are doing whether it is correct or wrong.They Just would prefer not to be failures, so they adjust and do what their friends do. They hookup, do irregular sex, be a tease, and that is it. No one thinks about one another inclination as long as you are getting what you need, everybody profits by everybody. At last, web has assumed a major job in the young person's reality as well as in everybody's reality. Time has changed; innovation is showing signs of improvement a seemingly endless amount of time aft er year. â€Å"Relationships† are currently an old design approach to go out with a person/young lady and at long last somebody's heart will be broken.Hooking up won't get anybody's heart destroy, it is Just you would what you like to without any cutoff points or rules as long as at long last they are Just called â€Å"friends†. Work refered to Fox, Stuart. â€Å"Backbone adds new hazards to custom of dating†. Hyper Cot 2. Web Cot 4. Definitions: Most of young people who take part in hookups despite everything stress over being prudent. Cautious: having or demonstrating wisdom or practical insight in lead and particularly in discourse: judicious; particularly: fit for protecting reasonable quiet. Tall and thin Lanky: tall and lean, or long and slim: regularly used to propose ponderousness in appearance or step.

Ancient Roman Meals :: essays research papers

Antiquated Roman Meals      The antiquated Romans were like todays ages in their eating propensities yet never ate three generous dinners daily. Ientaculum and prandium were just tidbits that filled their stomachs unitl the enormous cena, the occasion they anticipate since arousing. They had names for their suppers like our own, breakfast (ientaculum), lunch (prandium), and supper (cena).      Breakfast, ientaculum was typically taken around nine o'clock and comprised of simply a couple of bits of bread sprinkled in salt or dunked in wine, and with a scarcely any raisins and olives, and a little cheddar included. The least fortunate Romans ate minimal other than wheat either squashed to make a porridge or ground into flour for bread.      Lunch, or prandium was normally taken around early afternoon. It was normally nothing in excess of a bit of bread joined by chilly meat, vegetables, and natural product washed down with a glass of wine. Both ientaculum and prandium were so short there was no compelling reason to prepare the table or wash ones hands.      The just genuine feast was the night supper or cena. Supper time was for all intents and purposes the equivalent for all Romans because of the absence of counterfeit light. Supper was after the shower toward the finish of the eigth hour in winter and at the ninth in summer. The food is generally chilly,- breads, servings of mixed greens, olives, cheeses, and meats remaing from a nights ago supper. Every so often, hot dishes, for example, ham and pig's heads are eaten upon. Some rich Romans would have upwards of seven courses to benefit from.      Trimalchio, a rich Roman would have a tanned jackass with hors d'oeuvre dishes of olives, stuffed dormice abounded in nectar and poppy seed, hot hotdogs were laid on a silver flame broil close to pomegranate and damson seeds. The visitors were as yet occupied with the appetizers when a plate would be acquired with a container on it, in which there was a wooden hen spreading her wings. Under the straw were Peahen eggs that would base dropped. Each egg contained a fat becafico moved up in spiced egg yolkf. There were plates with the twelve signs of Zodiac on them that had food matas ching the image, smash, bull, crab, figs, lion, and so on. A few hosts would warm a wfshole pig and afterward engage his visitors by having talented swordmen cut the dad fig like he was executing it. In the wake of eating, numerous visitors would engage each othed sfr in burping. It was thought of gracious to burp and discharge wind after a ni sce feast. Visitors would basically snap their fingers and hirelings would come running with jars to contain pee.

How You Can Start A Business With No Money

How You Can Start A Business With No Money How many times have you heard aspiring entrepreneurs lament that, if only they had money, they would have been able to set up their own businesses and even expanded it? It is a generally accepted fact that, in order to start a money-making venture, you have to have money to kick things off. But what if you do not have money? Is it still possible to start a business?Surprisingly, the answer is yes. And that is what we will look into in the succeeding discussion. © Shutterstock.com | JingaIn this article, I will explore 1) the tips and methods on how you can start a business with no money, 2) success stories, and 3) start today.TIPS AND METHODS ON HOW YOU CAN START A BUSINESS WITH NO MONEYHere are some useful tips or methods that you can follow if you want to start a business, but you do not have money as starting capital.A.     Create what you canThis is common sense, really, and a principle that all aspiring entrepreneurs should follow. Start a business in an area that you know, or are familiar with. Keep in mind that you already lack in financial resources; add a very steep learning curve about your target business, and you will have more difficulty getting started.So how should you get started? The first step to take is to find out what you are familiar with, and what you are good at. List them down, no matter how personal they are. Are you skilled in construction? Are you the artistic type? Perhaps you are good in dealing with various t ypes of people and personalities. Maybe you are skilled in computers.Listing them down will help in making things more concrete for you. From there, you can assess whether the business idea currently brewing in your head will pan out, considering your strengths and know-how.Once you have cleared that stage, it is time to decide the options available to you, and they include some of the following:1.     Make something with the intention of selling itIf you are good with your hands, this will be no trouble at all. Of course, considering the fact that you do not have money, you won’t be able to hire workers to create the product for you. That means you only have yourself to rely on. Therefore, it is up to you to make the product that you will sell.Granted, making something will still entail a bit of cash outlay, considering you need to purchase some supplies. But that is just the initial cost, and if you play your cards right, you will be able to sell the product for an amount that i s significantly more than the initial cost you paid for the supplies or raw materials.But making the product is not all there is to it. You also have to consider the platforms where you will sell your goods. Say, for example, that you are very good in baking pastries. You have the baked products, but where will you sell them? You could probably go door to door, personally bringing your products to places where your target customers are, such as offices and schools. Some even go as far as bringing their samples to already established bakeries, coffee shops, and stores. The more tech-savvy individuals will make use of the internet, advertising their baked creations to their social circles.Let us take a look at some of the more popular platforms available to budding entrepreneurs.Etsy is now a household name, having established itself as one of the largest online markets for handmade goods. Etsy demonstrates a classic case of making something with what little resources you have and sel ling it at a premium. Here, you will find vintage and handmade items, ranging from jewelry to household items, toys, and educational items.eBay is also another of the most recognizable names when it comes to buying and selling online. In fact, you will often hear people say that if you have something to sell, post it up on eBay. Through the years, eBay has evolved and came to introduce various features that simplify the selling and the buying process, from ordering to payment.Bonanza is yet another online marketplace where entrepreneurs can sell their goods and wares. List your items for free, sell them to buyers expressing their interest, and get the sales, giving a small percentage to the website for acting as an intermediary.2.     Provide your services to those that need it.You cannot make anything, but you can probably perform an action for someone. This means you will be providing a service for others, in exchange for a fee. Delivery and courier services may have started this way, too.Just like when you create a product for selling, it is also important to identify the platforms for selling your services.3.     Resell something.Do you have items that are still in good condition that you no longer have use for, but will still have value for others? They may be interested to purchase them once you resell them. If you don’t own any, why not look for items that you can resell? Try scouring thrift stores and garage sales, and you will be surprised at the gems that you will stumble upon. Some may be sold as they are while others may require some rework or modification. Still, you can still fetch a handsome price for them where you will make more than a decent profit.Reselling is not limited to used goods alone, since you can also get into the act of buying something to resell it at a higher price. But what if you don’t have money to buy the items that you will be reselling? Another alternative is consignment. This is an arrangement between a consignor and a consignee. A consignor leaves his products or goods in the possession of the consignee, who is tasked to sell them. A large percentage of the sale will go to the consignor, and a lesser percentage will be left with the consignee, who did the actual selling.There are many advantages to building your business around what you know instead of veering off outside your comfort zone.You don’t have to waste time and money in learning a new skill that is related to the idea you are planning to launch as a business, because you already have firsthand knowledge about it.Since you are already an expert in that area, you no longer have to bring in consultants or other experts to help you out. It is your business, and you know best.There is another thing that you should take into consideration aside from your knowledge and skill set: your interest. You must have an interest or passion for that idea. Otherwise, you will not have enough motivation to see it into fruition. Besides, it is more fu n to be doing something that you actually enjoy, rather than something that you have to do in order to earn money.B.     PivotingThis method essentially involves providing services in order to generate cash flow that, in turn, will be used to fund the manufacture of products. That is to say that the main goal of the business from the beginning was to sell a product, and not to sell a service. Being a service provider is just a means to an end; in this case: funding a products-based company. Hence, the term, “pivot”.Some software companies start in this manner. Since they do not have enough money to fund their product development projects, they are willing to work for other, bigger, software companies, performing services such as software integration or testing services. The cash that they are paid from performing these services will then be used to fund their own product development.C.     GrindingAs a business owner, especially one with not enough money, you would have to be wi lling to go into the trenches, so to speak. Do the menial and manual labor, if you have to. Since you cannot afford to pay people to do the hard work for you, you have to do it yourself. Meet up with potential customers and suppliers and negotiate with them face to face. Knock on doors, pound the streets, and do all the work. Yes, you have to grind and sweat it out.Be present at ground zero. You still cannot afford to launch a marketing campaign or pay for ad spaces. That is not a problem; you can be your advertiser. Tell everyone what you are doing or what you are up to. Let your family, friends, acquaintances and other contacts about your new business and what you are offering. Ask them to spread the word and let this be the beginning of your business being introduced to more customers.D.     DifferentiationMake yourself stand out. When applying for a loan, for example, how can you convince your potential creditors that you are a good bet? If you have a letter of commitment from a n investor with a good reputation with the creditor you are applying to, this would definitely help a great deal. It will also be in your favor if you are able to present a contract for future revenue, showing your potential creditors that you will be able to have revenue coming in.E.     Seek financingThere are funding sources everywhere, and there is bound to be one that is perfect for you, if only you know where to look. And only if you do try to look.As much as you want to start your own business on your own steam, it is still an inescapable fact that, sometimes, you cannot do it alone and you need help. If you are averse to applying for a loan from banks and other financial lending institutions, there are still some ways that you can finance your business.1.     Get a line of credit.Fortunately, there are now a lot of banks or institutions that offer credit lines specifically designed for startups, so that they can grow, especially during the early stages of operation. This is especially useful for working capital purposes.Many startups make the mistake of incurring too much debt that they get buried in it. Avoid amassing too much debt when you are still in the early stages of the business. Do not pay all your expenses using your credit card, especially when you already have some revenue that you can use. You will find that you may end up paying more in finance charges and interest.2.     Consider using a business incubator sponsored by colleges, universities, and local economic development agencies or organizations.Incubators are programs that provide funding specifically meant as financial assistance to startups. One of the most common types includes offering office or business space, so the startups do not have to spend too much on overhead. Even shared administrative services are also offered.3.     Look into the possibility of using crowdfunding platforms.In crowdfunding, a business idea is pitched to the public, with the intention of seeking funding . The public will then invest a small percentage of money to fund the product development project, with the understanding that they will have priority for buy-ins in the future when the product has been fully developed. Raising the money is done typically via the internet. The entrepreneur will initiate the project by making the proposal; groups or individuals that are interested in the project will come forward and show their support through giving monetary contributions; and a platform acts as a moderating organization, serving as a bridge between the two parties.The most popular crowdfunding platforms today are Kickstarter, GoFundMe, and IndieGoGo.4.     Seek out an accelerator.The concept of accelerators is similar to that of business incubators. The only difference is that an accelerator expects a faster response to its investment, hence its name. Business incubators relatively take a longer time.SUCCESS STORIESNow let us take a look at some success stories where the founders o f the businesses were able to grow their businesses that they have started with little to no money. If we’re going to start naming examples, a classic scenario would be of Disney.Walt Disney grew up in a farm, but he had exceptional talent in drawing. He first started earning money by drawing pictures for his neighbors, and moving on to making advertisements, using his skills as a cartoonist. Soon, he was known to be one of the pioneers of animation, founding one of the most enduring companies in film, media and entertainment.But here are a couple of more recent examples.Nasty Gal is now one of the most recognizable names in fashion retail aimed at young women. But did you know that Nasty Gal founder Sophia Amoruso started out in 2006 by selling old pieces of clothing? She started by opening a store on eBay, where she put old clothes that she purchased for cheap at thrift shops and secondhand stores. Soon enough, she was able to establish her store as a reliable source of vintage fashion.In one article, Amoruso disclosed that, on one of her forays in a Salvation Army store, she was able to score a Chanel jacket for only $8. When she sold it at her shop, she was able to get more than $1,000 for it.Amoruso did all the hard work herself from the beginning. She personally scoured the secondhand stores and hunted for vintage pieces. She also served as the product manager, styling the pieces, taking photographs of them, and writing product descriptions for each item. When orders came in, she was the one who personally packed and shipped them to the buyers. Aside from using eBay, she also connected to customers through her MySpace account.Today, Nasty Gal now has its own website and domain, and employs more than 200 people. It has also launched its own apparel and accessories lines and collections, such as Shoe Cult, Nasty Gal Denim Collection, Nasty Gal Lingerie, and Nasty Gal Swimwear. In December 2014, it also branched out in the cosmetics field by partnering wi th MAC Cosmetics.Did you know that Mattel (yes, the company responsible for young girls everywhere wanting to live vicariously through Barbie and her beau, Ken) started out making and selling picture frames? Married couple Elliot and Ruth Handler started making picture frames from their garage in South California. From the scraps of the picture frames, they started making dollhouse furniture. This became a hit, and so they left picture frame making altogether and concentrated on toy-making instead, taking advantage of the baby boom at the time.They came up with a string of toys that met moderate success. It wasn’t until they released Barbie that they finally hit the jackpot. It certainly has come a long way from that small business that started operating from a garage.START TODAYDo not make having no money as an excuse not to start your business today. If you think you have a good business idea, and now is the perfect time to get it off the ground, and then do so. Strike while the iron is hot â€" yes, even if you have no money. There are ways to start your business even if you are financially strapped.

What Is a Plant in the Study of Economics

In the study of economics, a plant is an integrated workplace, usually all in one location. A plant generally consists of the physical capital, like the building and the equipment at a particular location that is used for the production of goods. A plant is also called a factory. Power Plants Perhaps the most common phrase associated  with the economic understanding of the term plant is the power plant. A power plant, also known as a power station or generating plant, is the industrial facility  involved in the generation of electrical power. Like a factory where goods are manufactured, a power plant is a physical location  where utilities are generated. Most power plants generate electricity through the burning of fossil fuels such as oil, coal, and natural gas. In light of the modern push for more renewable sources of energy, there are also plants dedicated to the generation of power through solar, wind, and even hydroelectric sources. Power plants that harness nuclear energy are a frequent subject of international discussion and debate. The Economics of Plants Though the word plant is sometimes used interchangeably with the words business or firm, economists use the term strictly in relationship to a physical production facility, not the company itself. So rarely is a plant or factory the sole subject of economic study. Rather, it is generally the business and economic decisions that take place surrounding and within the plant that are the topics of interest to economists. Taking a power plant as an example, an economist might be interested in the manufacturing economics of the power plant. This is generally a matter of costing, which involves both fixed and variable costs. In economics and finance, power plants are also considered long-lived  assets that are capital intensive, or assets that require investments of large sums of money. As such, an economist might be interested in performing a discounted cash flow analysis of a power plant project. Or perhaps they are more interested in the return on equity of a power plant. On the other hand, another economist might be more interested in the economics of plants in terms of industrial structure and organization. This might include an analysis of plants in terms of pricing decisions, industrial groupings, vertical integration,  and even public policy affecting those plants and their businesses. Plants also hold relevance in an economic study as the physical centers of manufacturing, the costs of which are very much intertwined with sourcing decisions and where companies choose to set up the manufacturing portion of their business. The study of the economics of global manufacturing, for example, is of constant debate in the financial and political spheres. In short, though the plants themselves (if understood as the physical location of manufacturing and production) are not always the primary subjects of economic study, they are at the center of real-world economic concerns.

Definition and Examples of Sound Change in English

In historical linguistics  and phonology, sound change has been traditionally defined as any appearance of a new phenomenon in the phonetic/phonological structure of a language (Roger Lass in Phonology:  An Introduction to Basic Concepts, 1984). More simply, sound change might be described as any particular  change in the sound system of a language over a period of time. The drama of linguistic change, said  English lexicographer and philologist  Henry C. Wyld, is enacted not in manuscripts or in inscriptions, but in the mouths and minds of men (A Short History of English, 1927).   There are many types of sound change, including the following: Aphesis and ApocopeAssimilation  Dissimilation and HaplologyLexical DiffusionMetanalysisMetathesisPrinciple of Least EffortProthesisSyncope See Examples and Observations below. Also, see: The Great Vowel ShiftGrimms LawIsoglossLanguage ChangeMutationPhonologyPronunciationWord Boundaries Examples and Observations An understanding of sound change is truly important for historical linguistics in general, and this needs to be stressed—it plays an extremely important role in the comparative method and hence also in linguistic reconstruction, in internal reconstruction, in detecting loanwords, and in determining whether languages are related to one another.(Lyle Campbell, Historical Linguistics: An Introduction, 2nd ed. MIT Press, 2004)Pronunciation of SchwaThere is a growing body of evidence that frequently used words quite often get affected early—an observation first made in the 19th century. . . .Consider the words adultery, century, cursory, delivery, desultory, elementary, every, factory, nursery, slavery. If possible, write them down on a piece of paper and ask several friends to read them out loud. Better still, get people to read sentences which include the words. For example: A cursory glance at the newspaper suggests that adultery is on the increase in this century. If you think slavery has been abolished, go and look at the factory at the end of our road. Every mother will tell you that nursery schools are a mixed blessing. Make a careful note of how the crucial words are pronounced, and see if your results agree with those of a linguist who carried out an investigation of this type.The investigator noted that, according to the dictionary, all words which are spelt with -ary, -ery, -ory or -ury are pronounced somewhat as if they rhymed with furry. The vowel preceding r is a so-called schwa, a short indeterminate sound written phonetically as [É™], and sometimes represented orthographically as er (British English) or uh (American English). In practice the schwa was not always pronounced. It was usually omitted in common words such as ev(e)ry, fact(o)ry, nurs(e)ry, which were pronounced as if they were spelt evry, factry, nursry with two syllables only. In slightly less common words, such as delivery, there was fluctuation. Some people inserted a s chwa, others omitted it. A schwa was retained in the least common words, such as desultory, cursory.(Jean Aitchison, Language Change: Progress or Decay? 3rd ed. Cambridge Univ. Press, 2001)Theories of Sound ChangeVarious theories of sound change, some of them proposed a century ago or earlier were current in the [19]70s. There was a longstanding traditional view about sound change being due to speakers modifying their pronunciation either to make it easier—to expend less effort—or to make speech clearer for the sake of the listener. Another one was espoused by Halle (1962) that language change, including sound change, served to improve grammar by making it more cognitively simple to compute. Postal (1968) suggested it was due to speakers desire for novelty, i.e., sounds change for the same reason that hemlines and haircuts change. Lightner (1970) claimed it was to avoid homophony--despite the abundant counter-examples that show homophony as the result of sound change. These are all teleological accounts, that is to say, they assume that the changes are purposeful, i.e., that they [are] motivated by a goal of some sort . . ..(John Ohala, The Listener As a Source of Sound Change: An Update. The Initiation of Sound Change: Perception, Production, and Social Factors, ed. by Maria-Josep Solà © and Daniel Recasens. John Benjamins, 2012)The Neogrammarian Regularity HypothesisIn the 1870s a group of linguists now generally referred to as the Neogrammarians created a lot of attention, controversy, and excitement with the claim that unlike all other linguistic change, sound change is regular and operates without exceptions.This Neogrammarian or regularity hypothesis led to a great deal of valuable and interesting research. However, as can be expected, such a strong claim did not remain without a good deal of often quite vociferous opposition. . . .[I]t is important to note that the neogrammarian regularity hypothesis has proved to be enormously fruitful, no matter how accurate it may be in fact. For it forces the linguist to look for explanations of apparent irregularity, either by establishing a non-phonetic source or through a better formulation of a given sound change. Either way we learn more about the history of a given language and about the nature of linguistic change than if we subscribe to a view that does not expect regularity in sound change.(Hans Henrich Hock, Principles of Historical Linguistics, 2nd ed. Walter de Gruyter, 1991)

Reaching Your Potential Free Essays

After I read this article I fond out that managing yourself is a good way to be successful. There are some strategies of how to achieve higher levels of success, such as knowing yourself, excelling at critical tasks and demonstrating character and leadership. The purpose is to clear understand who you are and what your dream is. We will write a custom essay sample on Reaching Your Potential or any similar topic only for you Order Now There is one strategies really touched me is that knowing your self from strengths and weakness can help you to achieve your dream or goal. First, knowing yourself is telling you to understand what are your strengths and weaknesses when you start your career. Some people can easily tell what are their strengths, but hard to defined the weakness. Talking to other people who knows you is a good way to get the answer. After finding the weakness and strength, the next thing is to ask yourself about what is your dream work and what do you enjoy doing? Then keep your strength and face your weakness in order to reach your full potential. I do agree this strategy and it helps a lot, I still remember when I started working, I wasn’t good at communication at first. However, my job required me to communicate with different manufactures, so I need to negotiate with different departments and sometimes I am asked to go to the factory to see the quality of samples. It requires a certain level of communication skills. In order to practice my communication skill, I try to write down my points before conversations. After a lot of time practice, I can clearly state my point of view. I faced my weakness in order to do well with my job. I think those practices not only improve my working ability but also having a good effect even up to now. Secondly, Excelling at critical tasks is to know how to develop your skills and how to distribute times after a critical business meeting. In order to reach your potential, it requires introspection and certain proactive behaviors. This strategy reminds me of my previews manager when I working in a French fashion company. She is good at using spare time to find useful information. In my memory, she always came to office half hour earlier and collected some latest news from fashion newspaper and websites, and prepared work to each designer. This is a good way to distribute times and practice the skill of colleting useful information. Last but not least is demonstrating character and leadership, a leader is a good decision maker and benefits the organization’s overall performance, and also they need to speak up and make better choices. I think leadership is a major element in management field, and better leadership can make company better organized. In conclusion, the advice for you to reaching your potential is to identify your dream, develop the skills after finding your weakness, and exhibit character and leadership. How to cite Reaching Your Potential, Papers

Frankenstein and Sleepy Hollow Essay Example For Students

Frankenstein and Sleepy Hollow Essay In this essay I will discuss the generic features of the Gothic Tradition. I will describe all of the aspects of the tradition and I will support the aspects with examples from well-known Gothic related films such as Dracula, Vincent, Nosferatu, Frankenstein and Sleepy Hollow. There are many common features in the Gothic Tradition; one of those features involves the use of a sense of atmosphere. In most Gothic films the weather usually is terrible. The weather tends to consist of either a storm or some is lightning. Also the atmosphere would be very dramatic. There wouldnt be very much daylight, so it would be dark. A full moon would be out as an extra to give a bigger feel for the atmosphere. An example of this type of atmosphere is well shown in Frankenstein. In the film Frankenstein a storm takes place. It is very dramatic because the scientist was in need for his creation to come to life. It was very dark and there was a full moon out, which gave the atmosphere a more frightening feel. There was also suspense to whether the creation was going to come to life. Also the film Dracula distinguishes a good atmosphere. In that film it was very dark and dingy. The setting is also another common factor. Most Gothic films set the scene in a castle, a haunted mansion, in an isolated forest or and old area. The features in a scene would include statues such as gargoyles. The area of these buildings would be uninhabited and isolated. If the scene were set in a castle there would be a laboratory and many secret passages. A good example that perceives a good setting is the film Sleepy Hollow. The scene was set in an isolated forest. There was the mystical tree, which separated the 2 worlds.Also another good example o f a good scene was well distinguished in the film Frankenstein. This is because Frankenstein has a good scene set in an old castle, which was isolated. There were also some secret passages. Dracula also was set in a castle, which was old, enclosed and huge in size. Emotions are another generic aspect of the Gothic Tradition. This emotion could be fear, frustration, panic and trepidation. A great example of this feature is shown in the film Vincent. Vincent the character himself was lonely because he had grief for his dead wife. He had love for his pets and his wife.He had a passion for his creation. With that creation he had malicious intent in mind. The film was very melodramatic. One more example was in the film Dracula where the vampire had the desire to suck blood from his victims and that was malicious intent. Characterisation is another aspect of the Gothic Tradition. In Gothic films there is usually a villain and a hero fighting for something. It turns out to be the primal fight between good and evil. There is sometimes a damsel in distress. There usually is a supernatural element. There is always purity and an impurity in a Gothic film. A good example is perceived in the film Sleepy Hollow. In that film there was the group who were the heroes and from the mystic tree the headless horseman came as the villain. The white horse was the purity and the headless horseman was the impurity. Another good example was set in the film Dracula. There was the vampire who was the villain and the boy who was the hero. There was a supernatural element in that film. The final generic feature in a Gothic film would include a theme. The themes commonly would be about good versus evil, death versus life, heaven versus hell, love versus hatred or finally despair versus hope. .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .postImageUrl , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .centered-text-area { min-height: 80px; position: relative; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:hover , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:visited , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:active { border:0!important; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .clearfix:after { content: ""; display: table; clear: both; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:active , .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .centered-text-area { width: 100%; position: relative ; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:hover .ctaButton { background-color: #34495E!important; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u3eaca6ed0e3fdcc1b0f0ec6469c12cfa:after { content: ""; display: block; clear: both; } READ: Dear Diary EssayAn example of this feature is well portrayed in the film Dracula. There is the evil that is Dracula and the good that is the boy. Also in Sleepy Hollow it was good versus evil and death versus life. In Frankenstein there was despair and hope to whether the creation would live or not. Finally in Vincent, there was the love for his wife and the hatred caused by her death.

Les Miserables Essays - English-language Films, British Films

Les Miserables LES MISERABLES Les Miserables is a story, a very long story, which has been categorized as a classic. The story is about 1200 pages long. It is an epic saga, which covers about three decades in the early 1800's of France. The film is about the fugitive, Jean Valjean, following his release from jail after doing nineteen years of hard labor for stealing bread. Jean Valjean is chased by the cruel and self-righteous Inspector Javert, in a lifelong struggle to evade capture. The novel, Les Miserables is internationally known. That is because of its universal themes. These themes are: how society treats its outcasts, and how it views its criminals, prejudice, justice, doing what is morally right, and people can become better persons. The theme -how society treats its outcasts- can be seen in how the poor and homeless are are treated, and that is like animals. The rich treat them as though they are inferior and that they have no feelings or any form of intelligence. They are also not given the right to vote, which makes them not citizens of that nation. This theme is universal because every nation in the world has some sort of outcasts in their land. In America, this theme can be related to the blacks. In the beginning of the twentieth century they did not have as much rights and oppurtunities as the whites. Another example of how this theme can be related to America is how a person with a southern accent is perceived as less intelligent, which is a false misconception. The theme -how criminals are viewed by society- can be seen by how Jean Valjean is treated after he is released by prison. Although, he has served a sentence of nineteen years, he is still chased and wanted. In that period of time when a person commited theft it was viewed as a crime against the community and that person should be punished to the most extremes. That theme can be seen in modern America. When a person commits a federal crime he\she cannot hold a public job or teach for the rest of his\her life. Also, when a person commits a crime, that person and that person's career is scarred for life. The theme -doing what is morally right- can be seen in many instances in the novel. One instance is Valjean gives money to free Cozzette. Another instance is Valjean does not kill Javert to save his life. Also, Javert lets Valjean go free. There are also times where people do something that is morally wrong, but lawful. One might be when the students are executed. Another might be the arrest of the prostitute. A present time situation might be soldiers killing other soldiers. It is legal, but is morally wrong. In conclusion, the novel, Les Miserables, is a universal book with themes that many people from many countries can relate to. That is why it is put in the class of classics. It is also popular because it can be related with present time situations and events.

The impact of technology on families and communities essays

The impact of technology on families and communities essays Discuss the impact of social, legal and technological change on individuals, groups, families and Communities As time moves on so does humanity and society we adapt and change as new knowledge and understanding is presented to us in different forms such as technologies, laws and social views all impacting on us within our homes and within our communities. Technology gets more and more advanced everyday its designed to entertain help and study humans it affects almost every aspect of the average persons life in one way or another wether that be machines in the work place the home computer or the knew technology that helps save lifes. Since the Industrial revolution which first occurred in Europe in the 1700s factories all around the world became involved with the new technology of the machine which in many ways replaced the manual human workers designed to help increase effiency and cost which has helped many companies consumers and workers and also buried some with jobs being replaced and people being put out of work which became increasingly the case with the introduction of computers with multiple task capabilities it could fill the job and effency of several workers. This effected society and communities drastically with unemployment levels soaring these levels decreased but the impact is still seen today with fewer jobs to go round. It hasnt all been negative though its also opened up paths for people who want to carry out a career with in technology such as IT workers etc and with a computer now in many homes schools and workplaces public understanding of technology has expanded and adapted to the changes with computers and machines being essential to run many business and carry out the day to day tasks we take for granted. Technology has also helped increase communication between nations, communities and individuals that once would not have been as easily accomplished; the internet has provided communicat...

Has the United Nations Failed to Fulfil Its Founding Promise to Research Paper

Has the United Nations Failed to Fulfil Its Founding Promise to Maintain International Security - Research Paper Example For the first time in the history of wars, America used nuclear weapons in WW2 and the world witnessed the destructive power of the nuclear weapons for the first time. Moreover, the potentials of a simple regional conflict in becoming a global conflict were also revealed to the external world through Second World War. Many countries forced to take part in the WW2 because of circumstantial pressure. The failure of League of Nations in preventing WW2 forced the global leaders to think in terms of a more powerful global body and the result was the formation of UN. Different subdivisions such as The General Assembly, The Security Council, The Economic and Social Council, The Secretariat, and The International Court of Justice etc were also formed inside UN in order to manage international disputes of various kinds. However, UN has failed to settle many of the international disputes developed after its formation and it failed to fulfil its founding promise to maintain international securi ty. UN & International security The 1971 Indo-Pakistan war is one of the major examples in which UN failed to interfere effectively. In 1965 also, both India and Pakistan engaged in a severe battle for the ownership of disputed Kashmir. Until now, Kashmir dispute has not been solved amicably and India and Pakistan come closer for a third battle recently after the 2008 Mumbai terrorist attack. In one of the recently revealed cables, WikiLeaks revealed how India and Pakistan responded immediately after the 26 November, 2008 Mumbai attack by Pak terrorists. In the days immediately after 10 Pakistani Lashkar e Taiba terrorists killed 166 people in Mumbai, a man pretending to be India's then External Affairs Minister, Pranab Mukherjee, called Asif Zardari, Pakistan's president, to warn it was about to launch a military response. President Zardari immediately contacted the country's military leadership and ordered its air force to be put on high alert to confront a possible Indian attack. He also mounted a diplomatic campaign to put pressure on India withdraw its "threat"(Nelson, 2011). Irrespective whether the revelation of WikiLeaks is right or wrong, one thing is sure; India and Pakistan came much closer for a war after the Mumbai terrorist attack and the international community is responsible for avoiding this war. United Nations has not shown many interests in preventing this war. In fact none of the UN officials have shown any interest in this issue. The disputes between India and Pakistan are widening gradually and international community is afraid of a possible war between these two nuclear powers in the near future. Even at the time of writing this paper 9on September 7 2011), televisions flash news show that more than 10 people were killed and around 50 people injured in Delhi because of a bomb blast suspected to be conducted by the Pak terrorists. It should be noted that in the five years alone, India suffered three or four major terrorist attacks from Pa kistan. All these terrorist attacks were happened because of the disputes over Kashmir. UN seems to be not learning lessons from past experiences. It should be noted that UN failed to prevent two Indo Pak wars and it is doing nothing to prevent a third possible war between these two Asian powers. The 2001 World Trade Centre attacks and the subsequent development of war on terror in Iraq and Afghanistan is another example for the failure of UN. It should be not

The Media and the Role They Play in Suicide Research Paper

The Media and the Role They Play in Suicide - Research Paper Example ion, arrest, punishment, embarrassment, and pity Case study 3: â€Å"Father of a gang-raped teenage girl commits suicide 'in shame'† A father to a 16-year-old girl committed suicide by taking poison after a gang of eight men raped his daughter Media shame led to Krishan’s completed suicide Change of writing styles With the discussions provided by Lester, it is agreeable that the media through publicized books fosters suicidal behaviors particularly to readers seeking information regarding suicide Classical writers applied writing styles such as: a. Romantics b. Boffo c. Irresistible Current writing styles such as: a. Spare b. Crafty c. Lyric Suicide related books have changed for the worse Statistics on suicide Data brought forward by National Violent Death Reporting System (NVDRS) document that people also commit suicide because of exposure to behaviours opined to suicide by media figures, family members, and peers Statistical figures showing the rate of suicide since year 1993 to 2010 After every 13.7 minutes, an individual dies through suicide in the US. Almost 1,000,000 individuals attempt to commit suicide every year. Ninety percent of those people who commit suicide have a treatable and diagnosable psychiatric disorder. Most people with mental illness do not commit suicide Medical costs amount to almost $100 million annually (2005). Conclusion The media, may it be publicized or viewed, play a crucial role in escalating the rate of completed, planned, attempted, and thought attempts especially among people undergoing certain challenges including diseases, depression, and disorders Recommendations People thinking of committing suicide should seek medical attention or counselling Researchers and doctors recommend specific forms of psychotherapy such as dialectical... This paper approves that The National Vital Statistics System of the United States reveals that, many people take their lives every year in this country. The research results point out that the risk of committing suicide is higher in some people than in others. According to the available data, the major causes of suicide in the US are depression, prior suicide attempt, suicide family history, and incarceration. Media plays a potential role in contributing to the suicidal behaviours of many Americans where firearms usage in movies and substance abuse take the largest percentage of deaths that occur due to suicide. This essay makes a conclusion that the media, may it be publicized or viewed, play a crucial role in escalating the rate of completed, planned, attempted, and thought attempts especially among people undergoing certain challenges including diseases, depression, and disorders. The market is flooding with movies where characters portrayed to have contracted killer diseases end up hanging themselves. This aspect affects people the third world countries, as their living costs are high. Television and the internet especially with the upsurge and accelerated use of social networks, live video coverage, and instant messaging are contributing to suicide behaviors every day. The discussed case studies show that the media facilitates death through suicide given that the antagonists of media’s role in suicide cases depicts that the involved people committed suicide due to the shame brought unto them by the media.

Vortioxetine: Long and Short Term Effectiveness

Vortioxetine: Long and Short Term Effectiveness Clinical Efficacy and Tolerability Studies:  Effectiveness in short term therapy Thase M et al. performed meta-analysis on 10 short term placebo-controlled clinical trials [studies analyzed were with Clinical trial registry no:NCT00839423, NCT00635219, NCT00735709, NCT01140906, NCT01153009, NCT01163266, NCT00672958, NCT00672620, NCT01179516, NCT00811252]outcome submitted to USFDA for vortioxetine approval purpose and demonstrate the efficacy of the compound in treatment of MDD. They observed existence of dose response correlation across the dosage strength (5-20mg/day) of vortioxetine on the basis of MADRS as efficacy measurement scale. The analysis reported clinically meaningful efficacy of vortioxetine through mean difference in change from baseline MADRS total score (32.4 ±4.1 for vortioxetine(n=2416) and 32.1 ±4.0 for placebo(n=1439)) observed for 5mg strength(difference of change in score: -2.6; p=0.008), 10 mg strength (-3.5; p The very first study to identify efficacy, safety and tolerability of vortioxetine 5mg and 10 mg/day dosage vs. placebo was carried out for 6 weeks with participation of 429 patients with baseline Montgomery–Åsberg Depression Rating Scale (MADRS) total score 30. Venlafaxine XR 225mg/day was used as an active reference in this multi-site study. The study exhibited superior treatment by vortioxetine in comparison of placebo as evident by significant difference (p Impairment in health-related quality of life (HRQoL) is a chronic illness directly related to depression. Improvement in HRQoL in patient suffering of MDD reflects therapeutic effectiveness and enhance patient adherence to the drug. Florea I et al. performed random effect meta-analysis on 9 placebo controlled short term studies [Studies included are Clinical trial registry no.: NCT 00839423; NCT00635219; NCT01323478; NCT00672958; NCT00672620; NCT00735709; NCT01153009; NCT01163266] of patients with MDD receiving vortioxetine using a variety of quality-of-life assessment tools. The meta-analysis (FAS, MMRM) showed a statistically significant difference from placebo in favor of vortioxetine (p Effectiveness on Cognitive function: Efficacy of vortioxetine on cognitive function in depressed adults Memory impairment as a Neurocognitive mutilation is prominent in patients with MDD and the same is considered s a marker of brain dysfunctinality (Burt D). Antidepresant drugs with positive effect on reversal of cognitive dysfunction are differenciated from the antidepressants with no cognitive effect to facilitate good prescription in general. In a preclinical study, Vortioxetine enhanced memory in rat as evident by novel object recognition test and alleviated extracellular level of acetylcholine and histamine when 1-10 mg/kg drug is administered subcutaneously to experimental animals (Mork A, 2013). The chronic dietary administration of drug also found to be effective in alleviation of stress-induced impairment in reversal learning when adult male rats were exposed to chronic intermittent cold (CIC) stress and 4-chloro-DL-phenylalanine methyl ester hydrochloride (PCPA), a 5-HT depleting agent (Wallace A, 2014). Restoration of 5-HT depletion impaired memory by Vortioxetine was also demonstrated by Jardin KG and Jansen JB through PCPA induced 5-HT depletion model and behavioural tests including object recognition (OR) and Y-maze spontaneous alternation (SA) tests respectively. SERT (Serotonin transporters) occupancy (>90%) by vortioxetine was established in their preclinical work, with reports of dose-dependently reversed recognition memory and spatial working memory in rats. Effectiveness in MDD relapse prevention (Long term therapy) Major depressive disorder (MDD) patients have to maintain therapy even after remission by acute treatment to prevent relapse especially when residual symptom and comorbid illnesses (E.g: MDD with generalized anxiety disorder) are present at the remission point (Keller M, 2007). The long term efficacy of antidepressants is also be established by study of its role in maintenance treatment in preventing depression recurrence in patients who responded to acute therapy (Kornstein 2006)(Steinert C 2014). Alam M et al (NCT 00707980) carried out an open-label, 52-weeks, long term study to identify efficacy of vortioxetine along with monitoring of adverse effects. This was the extension of two double blind, placebo controlled short term (8weeks) lead in studies involving participants suffering of MDD. Total 834 patients were treated with 5 mg/day dose of vortioxetine for first week followed by dose titration from 2.5 mg/day to 10 mg/day depending on intensity of response till 52 weeks. The study concluded with absence of potential adverse effect reports and proved efficacy of vortioxetine by maintenance of remission observed by Change From Baseline score of MADRS Total Score (Observation: -7.4  ±9.81 units Change from baseline score as end point result) and 24-item Hamilton Depression total score (Observation: -7.9  ±9.66 units change from baseline score as end point result). Furthermore, Baldwin DS et al reported safety and efficacy of vortioxetine in prevention of relapse of MDD o n the basis of 52 weeks of remission maintenance therapy in patients who previously completed acute therapy of vortioxetine for 8 weeks with evidence of remission. Patients reported approximately 8 points reduction from 13.5 ±8.7 base line MADRS score after 52 weeks of treatment indicated favorable profile of vortioxetine (2.5, 5 and 10 mg/day) in relapse prevention during long term remission maintenance therapy of MDD. At the end of 52 week treatment, approximately 2% patients have shown sign of relapse (MDRS score ≠¥ 22) as per Montgomery-Asberg Depression Rating Scale. For vortioxetine, a MDD relapse prevention study was carried out with participation of 639 MDD patients aged between 18-75 years and diagnosed with a current major depressive episode (MDE) within four weeks duration. In this investigation, against baseline score in MADRS scale ≠¥26, a remission point was considered as MADRS total score ≠¤10 for vortioxetine (5 or 10 mg/day) treated patients to enter in double-blind, 24 weeks phase of treatment with either placebo (n=192) or vortioxetine (n=204) for relapse time analysis. At the end of the study, relapse rate was 13% and 26% for vortioxetine and placebo treated groups respectively as an evidence of efficacy of vortioxetine in prevention of relapse in 396 patients participated in 24 week phase (Boulenger JP 2012). COMPARATIVE EFFICIENCY Treatment with vortioxetine (2.5 mg, 5 mg, 10 mg) failed to make differentiation from placebo when Change From Baseline in MADRS Total Score was considered as a primary efficacy analysis tool in a 8 Week randomized, double blind clinical study. In the same investigation, Duloxetine (60 mg), a reference drug used to find efficacy of vortioxetine, also failed to make differentiation against placebo in primary efficacy analysis. Secondary efficacy outcome analysis and tolerability analysis suggested efficacy of vortioxetine with 5mg and 10 mg strength through MMRM (Mixed-Effect Model Repeated Measure) model (Badwin DS, 2012). In a randomized, double blind study involving comparison of vortioxetine (n= 252) and agomelatine (n=241), superiority of treatment with vortioxetine (p Katona C et al reported significantly (P = 0.0011) higher efficacy of vortioxetine (5 mg/day) in comparison of placebo by 24-item Hamilton Depression Scale (HAM-D (24)) total score () as the primary measure. 29.2 vs. 19.3% remission rate were observed at the endpoint for vortioxetine and placebo controlled population respectively during the study which also involved duloxetine as active reference. The patient adherence rate was 94.2% in case of vortioxetine and 90.1% in case of duloxetine demonstrated tolerability of vortioxetine in their study. Comparative Safety of vortioxetine (10mg per day) in MDD treatment was established on the basis of 15 days study demonstrating its effect on psychomotor performance in 24 healthy subjects. The drug didn’t show alteration in psychomotor functioning withing and at the end point of te study. The investigation also involved use of Mirtazapine as an active reference which was found to be inferior through strandardized driving test due to cognitive impairment obsrved by it. (Theunissen). EFFECTIVENESS ON ETHNIC POPULATION Majority of the clinical investigations listed in table 3 were carried out at multi sites involving global population and diverse demographic distribution. The drug was found to be equally effective on participants from different countries. Recently H.Lundbeck announced head-to-head study results comparing efficacy and tolerability of vortioxetine 10mg/day and venlafaxine XR 150mg/day in treatment of MDD in 437 adult participants (Inclusion criteria: MADRS total score ≠¥26) from four Asian countries, Thailand, South Korea, Taiwan and China. The end point outcome established slightly more effectiveness of vortioxetine compared to venlafaxine with mean difference of -1.20 points in change observed in baseline MADRS total score(with 95% CI: -3.03 to -0.63). The superiority of vortioxetine was strongly supported by its tolerability data observed as lesser incidences of adverse events (6.6% vs. 13.7%) and lesser drop out ratio of participants (18% vs. 27.4%) in case of vortioxetine treatment compared to active reference. Efficacy of vortioxetine in Asian population was established by substantial improvement in MDD as evident by change in baseline score i.e.: -19.4 points on MADRS total score. SAFETY AND TOLERABILITY Efficacy and safety for Sexual function maintenance Sexual dysfunction is one of the major risks of antidepressant therapy particularly with selective serotonin reuptake inhibitors (SSRIs)(Strohmaier J 2011). Therapy discontinuation is reported frequently in clinical studies involving various antidepressants due to adverse effects associated with sexual problems which includes including anorgasmia, problems in ejaculation, absence of libido and impotence but still sexual dysfunction is one of the most under-rated AEs (Serretti A). at the same time symptoms and illness of depression is also known to be associated with sexual dysfunctions(Baldwin D, 2013 AND Foong T; Reichenpfader U,). In this dilemma, the data generated through efficacy and safety studies of vortioxetine are supporting the selection of vortioxetine as an antidepressant with the minimum side effects as far as sexual health impairment is concerned. A study involving MDD patients suffering of SSRI monotherapy (Treatment with citalopram, paroxetine or sertraline) induced sexual dysfunction indicated effectiveness of vortioxetine in clinically meaningful improvement in sexual functioning compared to escitalopram. This multicentre, randomized, double-blind, active controlled clinical trial was carried out on SSRI treated 447 participants who were already in partial or full remission state from MDD as measured by the MADRS and CGI-S/I(Clinical global impression severity and improvement scales). The participants were switched 10 mg/day fixed dose of vortioxetine or escitalopram for the first week of study. Further, the dose was increased to 20 mg/day in second week followed by flexible dose (10-20 mg/day) till the end of 8th week. The dose was taped down to 10 mg/day for escitalopram control group whereas vortioxetine treated group was switched to placebo control for another 1 week. Treatment with vortioxetine(n=169) concluded in a s tatistically significant treatment effect by change from baseline CSFQ-14(Changes in sexual functioning Questionnaire) total score at the end of 8th week of study in comparison of escitalopram(n=179). A mean treatment difference of 2.2 points for vortioxetine vs escitalopram groups(95% CI: 0.48—4.02; p=0.013, MMRM) proved efficacy of vortioxetine in sexual function restoration and MDD remission mintenance in patients treated with other antidepressant previously. Previously, during the proof-of-concept, short term efficacy study for vortioxetine (5mg/day and 10 mg/day) with placebo control and active reference control has demonstrated statistically higher safety of vortioxetine in comparison of active reference (12.4% incidences for venlafaxine vs. 1.9% incidences for 5 mg/day vortioxetine and placebo, p=0.0033, Fishers exact test) and equivalent safety in comparison to placebo group for the incidences of sexual dysfunction related adverse effects. In contrast, Mahbaleshwarkar 2013 (NCT00672620) reported high incidences (51% for and 37.5% for vortioxetine 2.5 mg and 5 mg versus 26.9% duloxetine and 33.3% placebo group) of treatment-emergent sexual function impairment by treatment with vortioxetine. They monitored sexual dysfunction as a adverse effect using the ASEX (Arizona sexual experience) scale. The study involving a total 9f 611 participants also concluded with observation of non-significant difference in changes from baseline of HAM-D2 4 total score between 5mg, 10 mg vortioxetine and placebo. The above studies indicate that sexual function related AEs is not a concern for long term use of vortioxetine as a remission maintenance therapy unlike other antidepressants whereas patients may suffer by adverse effects related with sexual dysfunction when the therapy for remission with 5mg or 10 mg dose is started in patients suffering of MDD. Adverse Effects Frequency and severity of adverse effect and change in selected vital body parameters, ECG, weight change due to vortioxetine (2.5, 5.0 and 10.0mg/day) administration were observed during a 52 week open labeled study by during a open label long term study by Baldwin DS. They also considered physical examination and clinical safety laboratory tests to make thorough investigation. Out of 535 participants, only 2% of individuals have shown sign of severe adverse effects but none of the adverse effect was prevalent in more than 0.56% individuals among total participants. Apart from this, majority of the patients reported the non-serious adverse effects have shown sign of nausea (19.81%) and headache (15.33%). Sexual dysfunction related adverse effects were reported in six patients at the end of the study. This study was also concluded with effectiveness of vortioxetine in long term treatment as mentioned previously in this article. The study was concluded with positive outcome in terms o f tolerability of vortioxetine for long term maintenance therapy in patients with MDD remission. Drug Interactions Vortioxetine dose adjustment is not required based on age, race, gender, ethnicity, renal or hepatic impairment but due to serotonin syndrome and neuroleptic malignant syndrome, the drug is contraindicated in concomitant administration with irreversible non selective MAOIs(Monoamino oxidase inhibitors). Chen G et al reported drug interaction cases affecting pharmacokinetic profile of vortioxetine in healthy subjects. They observed need of dosage adjustment of vortioxetin when it is concomminately administered with bupropion, rifampicin as steady state AUC and Cmax of of vorteoxetine enhanced by 128 and 114% in case of bupropion co-administration and suppressed by 72% and 51% in case of rifampicin co-administration. At the same time, tolerability of simultaneous therapy was evident by absence of any severe adverse effects. They also reported safety of vorteoxetine in concomminent administration of popular contraceptive, Estradiol. Vortioxetine is mainly metabolized in liver by CYP2D6 and up to some extent by CYP2C9 and CYP34/5. This makes vortioxetine sensitive to other drugs which are CYP2D6 inhibitors, CYP3A4 and CYP2C9 inhibitors and Cytochrome P450 inducers. Other than these, reversible and non-selective MAOI and serotonergic medicinal products are also potential drug substances affecting efficacy and safety of vortioxetine.

Business Edge Email

To: David Johnson Subject: Information on Business Edge Dear Mr David Johnson Firstly I would like to thank you for your response to my email based on my application for the sales and marketing position you are currently have available. I am pleased to know you would like further knowledge of my completion of the Business Edge Program undertaken through my Bachelor of Business at Edith Cowan University. The program helped me develop a range of skills related to the sales and marketing role in which I have applied for. The following email will represent the key aspects that Business Edge specified within my time in the program. I will analyze the different components of Business Edge and the skills I have gained during the program. Additionally I will explain how these concepts will be beneficial to your company. As a result this email will give you background knowledge on my intake and understanding of the Program. The Business Edge program is designed to help students understand the growing impact of international competition in businesses and employment and how to successfully operate in the global marketplace. The program introduces students to the concept of business and to various interpersonal, group work and organizational skills essential for university and employment success. The Program is also geared to helping students to realize and improve their abilities in individual learning styles, group work, cross-cultural communication, business communication, critical thinking and ethical behavior. In addition, the Business Edge program introduces students to the concept of self-reflection, self-discovery, self- criticism, peer assessment and information and time management. Having completed this program I can tell you that it is an extremely unique course as it focuses on student centered learning. This means that there are plenty of role-plays, scenarios, interactive multi-media and activities where students develop their employability skills by ‘doing’. As the student you must use your previous knowledge and experience, apply these to real situations and learn from those around you so that your employability skills can be developed and refined along the entire length of the program. A key attribute I have developed through the Business Edge program is the â€Å"ability to communicate†. This gives me excellent employability skills such as forming effective relationships with customers and employees. This is a perfect attribute for the sales and marketing role. As someone interested in sales and marketing I think it is essential that you communicate effectively and form networks with customers and fellow clients. I think the ability to interact with others openly and objectively is vital criteria for the position and Business Edge has certainly given me a great advantage in this area. The main emphasis that the Business Edge program projected was on clear communication and presentations. Personally I feel to be a competent communicator you must first be able to listen and understand others, in particular with sales because face to face communication is frequent and also phone conversation. I think my ability to understand clear communication and my advanced understanding of open questions will benefit your company greatly. I know when working in sales and marketing you have to allow communication to flow and invite open discussion. You must have a clear tone as well as a good posture if talking to an audience, when talking on a phone your manner must be polite while still being clear and able to adapt. I believe that a good communicator is someone who can change the way they communicate to suit the person they are speaking to. You should express yourself in a way that makes sense to that person. I think the Business Edge program has helped me achieve this and it will be a great asset in the sales and marketing role. Another attribute that I developed through the Business Edge program is the â€Å"ability to work in teams†. The Business Edge program as stated earlier is student centered and the learning process is by â€Å"doing†. Most of this is done through group work, participating in various activities and presentations. Through these activities I could improve my self-confidence to a higher level. I got an idea about how to work in groups with mutual understanding and to respect others ideas as well. With the knowledge I gained from this unit, I’m now able to get others give their ears to me and express my ideas in an effective manner in front of an audience.

A report on the serious failures of winterbourne view Essay

Winterbourne View, and the company Castle Beck Care LTD, failed to protect the individuals in their care from various types of abuse. They were not protected adequately from harm, risk and the own unsafe practices of the staff employed there. Staff at Winterbourne View had failed in their legal duty to notify the Quality Care Commission of serious incidents, including injuries to patients and occasions when they had gone missing. see more:identify reports into serious failures to protect individuals from abuse Ten essential standards, which the law requires providers to meet and Winterbourne View did not include; The managers did not ensure that major incidents were reported to the CQC as required. Planning and delivery of care did not meet people’s individual needs. They did not have robust systems to assess and monitor the quality of services. They did not identify and manage risks relating to the health, welfare and safety of patients. They had not responded to or considered complaints and views of people about the service. Investigations into the conduct of staff were not robust and had not safeguarded people. They did not take reasonable steps to identify the possibility of abuse and prevent it before it occurred. They did not respond appropriately to allegations of abuse. They did not have arrangements in place to protect the people against unlawful or excessive use of restraint. They did not operate effective recruitment procedures or take appropriate steps in relation to per sons who were not fit to work in care settings. They failed in their responsibilities to provide appropriate training and supervision to staff. The CQC report concluded that there were systemic failures in protecting people or to investigate allegations of abuse. Footage used in prosecutions showed member of staff repeatedly assaulting and harshly restraining patients under chairs, giving patients cold punishment showers, with one patient being left out in near zero temperatures and another having mouthwash poured in their eyes. Members of staff also pulled hair, poked people in the eyes, force fed medication and mocked patients to the extent one actually tried to escape through a second floor window to escape the torment. These are all massive failings of the staff and the company to provide a safe and secure environment for its service users. The CQC was also guilty of failing to investigate claims thoroughly. The case of Winterbourne View and the coverage that Panorama aired on television shocked the nation. Undoubtedly making a lot of people question the capability of the CQC as well as their local homes / services, where family members or friends may visit or live. The CQC held an internal inquiry and as a result there were many changes to various organisations. Winterbourne view inevitably closed and eleven people plead guilty to criminal offences of neglect or abuse. Six of which were jailed.

Details of James Deans Death in a Car Accident

In September 1955, actor James Dean was driving his brand-new Porsche 550 Spyder to an auto rally in Salinas, California, when he was involved in a head-on collision with a 1950 Ford Tudor. James Dean, only 24 years old, died in the crash. Although already famous for his role in East of Eden, his death and the release of Rebel Without a Cause caused James Dean to soar to cult status. James Dean, forever frozen as the talented, misunderstood, rebellious youth remains the symbol of teenage angst. Who Was James Dean? John Kobal Foundation/Contributor/Getty Images James Dean had appeared in a number of television shows before getting his big break in 1954 when he was chosen to play Cal Trask, the leading male role in the film East of Eden (1955). This was the only one of Deans films released before his death. Quickly following East of Eden, James Dean was signed to play Jim Stark in Rebel Without a Cause (1955), the film for which Dean is best remembered. Immediately following the filming for Rebel Without a Cause, Dean played the lead role in Giant (1956). Both of these films were released after Deans death. James Dean Raced Cars As Deans movie career began to take off, James Dean also started to race cars. In March 1955 Dean raced in the Palm Springs Road Races, and in May of that year he raced in the Minter Field Bakersfield race and the Santa Barbara Road Races. James Dean liked to go fast. In September 1955 Dean replaced his white Porsche 356 Super Speedster with a new, silver Porsche 550 Spyder. Bettmann/Contributor/Getty Images Dean had the car specialized by having the number 130 painted on both the front and back. Also painted on the back of the car was Little Bastard, Deans nickname given to him by friend Bill Hickman, who was Deans dialogue coach for Giant. The Accident On September 30, 1955, James Dean was driving his new Porsche 550 Spyder to an auto rally in Salinas, California, when the fatal accident occurred. Originally planning to tow the Porsche to the rally, Dean changed his mind at the last minute and decided to drive the Porsche instead. Dean and Rolf Wuetherich, Deans mechanic, rode in the Porsche. Following were photographer Sanford Roth and Bill Hickman, driving a Ford station wagon that had a trailer for the Spyder attached. En route to Salinas, Dean was pulled over by police officers near Bakersfield for speeding around 3:30 p.m. After being stopped, Dean and Wuetherich continued on their way. Two hours later, around 5:30 p.m., they were driving westbound on Highway 466 (now called State Route 46), when a 1950 Ford Tudor pulled out in front of them. 23-year-old Donald Turnupseed, the driver of the Ford Tudor, had been traveling east on Highway 466 and was attempting to make a left turn onto Highway 41. Unfortunately, Turnupseed had already started to make his turn before he saw the Porsche traveling quickly toward him. Without time to turn, the two cars smashed nearly head-on. The injuries among the three involved in the crash varied greatly. Turnupseed only received minor injuries from the accident. Rolf Wuetherich, the passenger in the Porsche, was lucky to be thrown from the Porsche. Although he suffered serious head injuries and a broken leg, he survived the crash. Dean, however, was killed in the accident. Dean was just 24 years old at the time of the wreck. Posthumous Academy Awards To this day, James Dean is the only person to receive two Academy Award nominations posthumously. In 1956, he was nominated posthumously for Best Leading Actor for his role in East of Eden. This was a historic first. In 1957, Dean was again posthumously nominated for Best Leading Actor, this time for his role in Giant. What Happened to Deans Smashed Car? Many Dean fans wonder what happened to the smashed Porsche. After the accident, the crumpled car was toured around the United States as part of a driver safety presentation. However, en route between two stops, the car disappeared. In 2005, Volo Auto Museum in Volo, Illinois, offered $1 million to anyone who currently had the car. So far, the car has not resurfaced.